Teri Hatcher (Susan Mayer)
Hatcher cruised on "The Love Boat" and hung out with Superman (a.k.a. Dean Cain) on "Lois and Clark" before moving onto Wisteria Lane. She's also earned a Golden Globe® for her performance on this series.
Felicity Huffman (Lynette Scavo)
Huffman won an Emmy® for her role on the show (the only Housewife do so) and an Oscar nomination in the same year for "Transamerica." FYI: She's married to actor/director William H. Macy.
Marcia Cross (Bree Van De Kamp)
Cross got her big break when she landed the memorable role as the psycho Kimberly Shaw on "Melrose Place." Her other TV credits include "Everwood," "The King of Queens" and "C.S.I."
Eva Longoria (Gabrielle Solis)
Longoria comes from the soap world, having starred on "The Bold and the Beautiful," "General Hospital" and "The Young and the Restless." (Also a model, Longoria is signed with L'Oréal.)
Nicollette Sheridan (Edie Britt)
Sheridan has had plenty of experience playing vixens from her "Knots Landing" days to her many TV movies, such as "Deceptions" and "Shadows of Desire." She's currently engaged to singer Michael Bolton.